Most carrier isolates are shown to lack capsule production. Nndss data reported by the 50 states, new york city, the district of columbia, and the u. Ppt neisseria powerpoint presentation free to download. Neisseria meningitidis the meningococcus causes significant morbidity and mortality in children and young adults worldwide through epidemic or sporadic meningitis andor septicemia. Etest as susceptibility test for evaluation of neisseria meningitidis isolates article pdf available in journal of clinical microbiology 329. Neisseria meningitidis is the most common cause of bacterial meningitis in children and young adults worldwide. Neisseria meningitidis colonies meningococcus on a. Pathogenic neisseria meningitidis utilizes cd147 for. Identification of neisseria meningitidis serogroups y and. We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. The complete gonococcal cryptic plasmid and hinfi derived digestion fragments subcloned into escherichia coli were used to probe southern blots of plasmid extracts. Pdf etest as susceptibility test for evaluation of. The bacteria were allowed to adhere to polydlysinecoated glass and observed over a period of 60 s, with 12 images acquired per second. K v chakradhar assistant professor department of microbiology nriims 2.
To date, antibiotic resistance is relatively uncommon in n. Neisseria meningitidis the meningococcus is the cause of epidemic meningitis, a fulminant sepsis meningococcemia, milder bacteremia, and, less commonly, other focal infections. Chapter 1 epidemiology of neisseria meningitidis neisseria meningitidis, also known as the meningococcus, is the bacterium responsible for meningococcal septicaemia and meningitis in humans. Neisseria meningitidis induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. Neisseria meningitidis mechanisms of pathogenicity. The human species is the only natural host of neisseria meningitidis, an important cause of bacterial meningitis globally, and, despite its association with devastating diseases, n.
Gsk combining factor h binding protein fhbp, neisserial heparin binding protein nhba, neisserial adhesin a nada, and poracontaining outer membrane vesicles was recently approved for. Neisseria meningitidis is one of the major causes of bacterial meningitis, and serogroups a, b, c, y, and w5 account for most disease worldwide. See bacterial meningitis in children older than one. The etiological agent is neisseria meningitidis, a gram negative diplococcus and an obligate human pathogen. Meningococcal antigen typing system matsbased neisseria. During an epidemic a situation that is more common outside of the united states, secondary attack rates in family members may be as high as 4% to 5%.
Meningococcal meningitis and sepsis are devastating diseases which still affect people with an incidence varying between 0. Characterization of motility and piliation in pathogenic. Meningococcal disease american academy of pediatrics. Neisseria of the eleven species of neisseria that colonize humans, only two are pathogens. Both sporadic and epidemic disease can occur, and a large number of individuals can. Homology of cryptic plasmid of neisseria gonorrhoeae with. It causes the only form of bacterial meningitis known to occur epidemically. Part of the explanation for this phenomenon is the fact that meningitis due to neisseria meningitidis tends to strike young, previously well individuals and can progress over a matter of hours to death. The neisseria genus contains eleven species that colonize the oropharyngeal and urogenital mucosa of humans and of these, neisseria gonorrhoeae and n. Neisseria meningitidis causes approximately 3000 cases of invasive disease annually in the united states.
Now customize the name of a clipboard to store your clips. Surveillance of antimicrobial resistance in neisseria. Laboratory methods for the diagnosis of meningitis. Chapter 7 identification and characterization of neisseria. Thirteen of 24 patients had at least one episode, and usually two or more episodes of neisseria meningitidis or neisseria gonorrhoeae bacteremia, or both. Prevention of neisseria meningitidis american academy of. Infection with neisseria meningitidis can produce a variety of clinical manifestations, ranging from transient fever and bacteremia to fulminant disease with death ensuing within hours of the onset of clinical symptoms. Meningococcal meningitis and meningococcemia are the 2 clinical syndromes with which it is traditionally associated, resulting from invasion of the local tissues into the bloodstream. Clipping is a handy way to collect important slides you want to go back to later. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. These are provisional cases of selected national notifiable diseases, from the national notifiable diseases surveillance system nndss.
If you continue browsing the site, you agree to the use of cookies on this website. Meningococcal meningitis, meningococcal infection, cerebrospinal fever. Neisseria meningitidis exists as normal flora in the nasopharynx of up to 515% of adults. We read with interest the report by cunningham and colleagues regarding the inability of matrixassisted laser desorption ionizationtime of flight mass spectrometry malditof ms to differentiate neisseria meningitidis from neisseria polysaccharea.
Neisseria meningitidis is immediately reportable on first knowledge or suspicion of the diagnosis due to the potential need for prophylaxis of close contacts within 24 hours of suspected diagnosis suspicion is normally based on gram stain results see table on page 4. Compared to streptococcus pneumoniae and acinetobacter baumanni, meningococcal viability after desiccation on plastic, glass or metal surfaces decreased rapidly, but viable. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Bacteraemic pneumonia caused by neisseria meningitidis. Neisseria meningitidis is the causative agent of potentially fatal meningitis and septic shock, induced by bacterial colonization of blood vessels in the brain and the periphery. Cellular and molecular biology of neisseria meningitidis. Neisseria meningitidis meningococcus dr kamran afzal slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Neisseria meningitidis material safety data sheet infectious substances section i infectious agent name. Infection of the genitals can result in a purulent or puslike discharge from the.
Dna probe hybridisation was used to examine the relation between the cryptic plasmid from neisseria gonorrhoeae and plasmids carried by pharyngeal isolates of neisseria meningitidis and neisseria lactamica. Microbiology test reliability in differentiation of. Opa proteins of neisseria meningitidis exhibit translational phase variation via addition or deletion of repetitive coding repeat units. To characterize motility in pathogenic neisseria, we studied twitching motility using livecell phase contrast imaging and automated particle tracking of moving bacteria.
To describe the antimicrobial resistance profile of neisseria meningitidis isolates causing invasive disease in brazil from 2009 to 2016. Isolation of moderately penicillinsusceptible strains of neisseria meningitidis in argentina. Morphology capsulated gram negative cocci in pairs diplococci 0. During periods of endemic disease, about 10 % of the general population harbour neisseria meningitidis in the nasopharynx. A high rate of nasopharyngeal carriage occurs in household contacts of persons with invasive disease. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Neisseria meningitidis and gonorrhoeae, haemophilus. Infections caused by the neisseria meningitidis bacteria invasive meningococcal disease imd is a lifethreatening condition caused by the bacterium neisseria meningitidis n. Neisseria meningitidis is the bacterium that causes meningococcal disease, one of the leading sources of communityacquired sepsis and meningitis among children. Endotoxin, capsule, and bacterial attachment contribute to. To escape the bodys defences, the major asset of n. As highlighted in the article, these two neisseriae are also difficult to distinguish by biochemical methods. The rapid and accurate characterization of meningococci is crucial for effective public health management.
Neisseria meningitidis is an extracellular pathogen, meaning that it colonizes and proliferates in the extracellular fluid and blood. Neisseria meningitides is an aerobic, nonsporeforming gramnegative coccobacilli that resides in its natural habitat within the nasopharyngeal tract of humans. Mortality can be very high if the infection is not treated appropriately, and longterm sequelae can be severe even in successfully managed cases. Meningococci colonize the nasopharyngeal mucosa of approximately 10% of healthy individuals but can cross epithelial and endothelial cell barriers and enter the bloodstream, causing. Meningococci only infect humans and have never been isolated from animals because the bacterium cannot get iron other than from human sources transferrin and lactoferrin. Swift serogroup determination is essential, particularly during case clusters and outbreaks, while the changing epidemiology of this. Chapter 7 identification and characterization of neisseria meningitidis. Brain sciences free fulltext neisseria meningitidis. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Neisseria meningitidis an overview sciencedirect topics. Neisseria meningitidis is transmitted through the inhalation of large human respiratory droplets, but the risk from contaminated environmental surfaces is controversial.